Nutrition and obesities : systemic approaches

Team

Leaders: K. Clément (PU-PH) and J. Aron-Wisnewsky (MCU-PH)
Team Contributors: R. Alili, C. Poitou, S. André, I. Dugail, M. Guerre-Millo, N. Sokolovska, H. Soula
Main collaborators: JD. Zucker, International consortia Metacardis, ePos, Litmus (IMI2), INRA

Main Objectives

• Define gut microbiota signature in CMD and evaluate the impact of environment (diet and drugs)
• Demonstrate causality of CMD microbial signature in the development of CMD or its resolution:
  • in human interventions: Metacardis follow-up (development), diet or bariatric surgery (reversal)
  • in mice: gut microbiota transfer experiments (induce CMD or its reversal)

Team

Leaders : A. Ribeiro (CR INSERM), S. André (MCU SU), P. Serradas (PU SU)
Team contributors : C. Amouyal, L. Genser, A. Leturque, C. Osinski, C. Poitou, H. Soula, F. Andreelli
Main collaborators: P. Collombat (France), U. Meinzer (France), C. Alvarez (Espagne), C. Magnan (France), G. Gorochov (France), R. Regazzi (Suisse), G. Mithieux (France).

Main Objectives

The intestine is a target for changes in external (food, microbiota) and internal (immune system) environment. Gut adaptation has in turn consequences on gut immunity, epithelial cells homeostasis and key organs for energy balance.

Team

Leaders : I. Dugail (DR INSERM) and G. Marcelin (Post-doc)
Team Contributors: C. Rouault, C. Gamblin, M. Guerre-Millo, J. Aron-Wisnewsky, F. Marquet, P. Bellassen, K. Clément
Main collaborators: L. Yvan-Charvet (F), E. Gautier (F), G. Desrumeaux (F), A. Fereira (Brasil), F. Charlotte, G. Le Naour, D. Sasson (Inserm F)

Main Objectives

• Understand white adipose tissue (WAT) fibrosis : role of progenitors
• Characterize WAT senescence :
  • Evaluate inappropriate turnover of subcellular components (Lysosomal degradation)
  • Examine PG as gut-derived signaling modulators in AT remodeling

Team

Leaders: N. Sokolovska (MCU SU) and H. Soula (PU SU)
Team contributors: F. Jacques (IE), All team members (link with experimental and clinical approaches).
Main collaborators: JD. Zucker (DR IRD / SU), E. Prifti (IR ICAN),  E. Belda (IR, ICAN), Y. Chevaleyre (PU P12), B. Hanczar (PU Evry), P.-H. Wuillemin (LIP6, SU), consortia internationaux (ePos, Metacardis, Litmus)

Main Objectives

We will develop innovative tools for data analysis, physiological status prediction, and visualisation in metabolic diseases. Convergence of techniques include statistical inferences, machine learning, and mechanistic approach using dynamical systems. This WP is strongly integrated with the other WPs which produce large-scale data.  

Team

Leaders: C. Poitou (PU-PH) and J. Aron-Wisnewsky (MCU-PH)
Team Contributors: K. Clément, P. Tounian, B. Dubern, F. Marchelli, F. Marchelli, L. Genser
Main collaborators: M. Tauber (F), S. Farooqi (UK), A. Rudich (Israel), P. Kuhnen (G)

Main Objectives

• Develop innovative diagnosis and predictive factors/tools 
  • for patient stratification
  • to predict poor responders’ outcomes after interventions (diet or bariatric surgery) or after treatment in genetic obesities
  • discover new mutation/genes/pathways in rare obesities
• Develop novel approaches for therapy with personalized medicine
  • improve the outcomes of poor responder’s response by adding other specific interventions (physical activity, specific diet, pre or prebiotic that modulates gut microbiota)
  • implement new treatments in rare obesities